Helen Nemanjić (?–1314)

Dmd058420 1314..1325

GSK1322322 (N-((R)-2-(cyclopentylmethyl)-3-(2-(5-fluoro-6-((S)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-2-methylpyrimidin-4-yl) hydrazinyl)-3-oxopropyl)-N-hydroxy-formamide) is an antibiotic in development by GlaxoSmithKline. In this study, we investigated the metabolism and disposition of [C]GSK1322322 in healthy humans and demonstrated the utility of the Entero-Test in a human radiolabel...

Dev115493 1305..1314

The genetic control of mammalian epithelial polarity and dynamics can be studied in vivo at cellular resolution during morphogenesis of the mouse neural tube. Themouse neural plate is a simple epithelium that is transformed into a columnar pseudostratified tube over the course of ∼24 h. Apical F-actin is known to be important for neural tube closure, but the precise roles of actin dynamics in t...

Helen.

Helen Dearden and Rosemary

Gestational trophoblastic neoplasia (GTN) includes the abnormal pregnancies complete (CHM) and partial hydatidiform mole (PHM) and the malignant gestational trophoblastic tumours (GTT) invasive mole (IM), choriocarcinoma, placental site trophoblastic tumour (PSTT) and epithelioid trophoblastic tumour (ETT). While many genetic studies have been performed in both CHM and PHM, similar studies of t...

A conversation with Helen Hobbs.

Helen Hobbs, an HHMI investigator, professor at the University of Texas Southwestern Medical Center, and director of the Dallas Heart Study, is best known for her research focused on identifying genetic factors that predispose people to developing metabolic disorders and heart disease. By studying outliers in the Dallas Heart Study, Hobbs (Figure 1) uncovered a genetic defect responsible for lo...